Tennessee (4-5) lost Locker when he suffered a Lisfranc injury to his right foot in the second quarter of Sunday's loss at home to Jacksonville. The focus now shifts to Fitzpatrick as he tries to help turn around a team that's lost four of five, is two games behind AFC South-leading Indianapolis (6-3) and hoping to avoid its first four-game home losing streak since 2005.
"We're just concentrating on these seven weeks," coach Mike Munchak said. "That's all we're concerned about. Right now we just got to go forward and try to win a game."
Tennessee has dropped eight of nine to the Colts, who it will face twice in three weeks. The Titans' lone win during that stretch came at home, 27-10 on Oct. 30, 2011.
Fitzpatrick completed 54.3 percent of his passes with a touchdown and four interceptions while starting for the injured Locker in consecutive losses to Kansas City and Seattle last month. He was 22 of 33 for 264 yards with two TDs, no picks and ran for a score in relief Sunday.
"When it's your turn to step up, you've got to step up and play, and that's where we're at," said tight end
"He's going to be the starting quarterback from now on because Jake is out for the year, so Ryan has no choice but to play (well). I feel like he did a great job against the Jaguars. This is his opportunity to be the man now."
Fitzpatrick could use some help from
After turning the ball over a season-high four times Sunday, the Titans have committed 13 in five games following a 3-1 start where they didn't have any.
Indianapolis has forced one or no turnovers in three of four games, and committed a season-high five during Sunday's 38-8 home loss to St. Louis. Andrew Luck threw three interceptions to match his total from the season's first eight games and the Colts allowed Rams rookie Tavon Austin to score on a 98-yard punt return and pass plays of 57 and 81 yards.
"I think all we want is to never play like that again," tight end Coby Fleener said. "The feeling after that game was just disgust."
Luck threw for a season-high 353 yards, but one touchdown and was sacked three more times, including one he fumbled and returned for a Rams TD. Luck did run for 17 of the team's 18 rushing yards.
Indianapolis has been held to 74 or fewer rushing yards in three of the last four contests. Tennessee ranks 21st allowing 114.9 rushing yards per game but held the Jaguars to 54.
"We realized how important the run game is to our success," Luck told the Colts' official website. "We'll improve, and we're looking forward to the Titans."
Defensively, Indianapolis has allowed at least 24 points in four of the last five games and five TD passes of at least 31 yards in the last three.
"Certainly we're not going to bury our head in the sand on this past ball game," Colts coach Chuck Pagano said. "We'll address the issues like we always address them. We know there are things that need to be fixed and we'll go to work on fixing those things."
Luck's 16-yard touchdown pass to Vick Ballard gave the Colts a 19-13 overtime win at Tennessee last season. He completed 58.3 percent of his passes with two TDs and three INTs while Indianapolis won both 2012 meetings by a combined 10 points.